• The structures of these compounds were confirmed

  2025-02-27

  

  The structures of these compounds were confirmed from their spectral and micro analytical data. Based on [M + H] 367, molecular formula of was established as CHON. The IR spectrum of showed atrial natriuretic peptide receptor due to CO stretching at 1700 Cm & OH stretching at 3188 Cm indicating t

• br Autophagy and cell death pathways in ischemic stroke

  2025-02-27

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic Fludara injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morphology

• CK is considered a central

  2025-02-27

  

  CK is considered a central controller of cellular energy homeostasis that catalyzes the reversible transfer of a phosphoryl group from ATP to adenosine diphosphate (ADP) and creatine to produce PCr [5]. This enzyme builds up a large pool of rapidly diffusing PCr for temporal and spatial buffering of

• br Discussion Herein we demonstrate that mice

  2025-02-27

  

  Discussion Herein, we demonstrate that mice deficient in L-12/15 LO are more sensitive to 3-NP-induced toxicity although a substantial individual variability in striatal lesion size in response to 3-NP in both genotypes was observed. This variability is not atypical; several studies demonstrate s

• In the pituitary of R quelen mRNA levels of cyp

  2025-02-27

  

  In the pituitary of R. quelen mRNA levels of cyp19a1b were found to be higher in males than females, suggesting a sex-specific function, and perhaps a local action to regulate gonadotropins or other pituitary hormone secretion (Olivereau and Callard, 1985; Zhang et al., 2014). Interestingly, the hig

• The putative residue apelin proprotein

  2025-02-27

  

  The putative 55-residue apelin proprotein (proapelin or apelin-55) is processed from a 77-residue preproprotein through removal of a 22-residue signal peptide (Table 1). Apelin-55 is further processed into bioactive isoforms of 36, 17, or 13 residues, likely through protease-mediated mechanisms. To

• It has been proposed that

  2025-02-27

  

  It has been proposed that a PrP pathogenic mechanism is a toxic gain of function secondary to the misfolding of mutated PrP. However, such a mechanism might not apply to all mutant PrP species, since some mutations had little effect on the stability and folding kinetics of PrP (Swietnicki et al., 19

• br Conflict of interest br Acknowledgement We wish

  2025-02-27

  

  Conflict of interest Acknowledgement We wish to thank the Program of National Key R&D Program of China (2017YFD0200500) and the Fundamental Research Funds for the Central Universities (KYTZ201604) for partially funding this work. Introduction Chitosan ((1→4)-2-amino-2-deoxy-β-d-glucose) is

• Azacyclonol br Acknowledgments br Introduction Alzheimer

  2025-02-27

  

  Acknowledgments Introduction Alzheimer's disease (AD) is a severe neurodegenerative disorder primarily affecting the elderly population. Senile plaques in the brain, one of the pathological hallmarks of AD, are formed by the accumulation of aggregated β-amyloid (Aβ) with an extensive β-sheet s

• br Conflict of interest statement

  2025-02-26

  

  Conflict of interest statement Acknowledgement Introduction Lipoxygenases (LOs) are enzymes catalyzing the positional as well as stereo-specific introduction of molecular oxygen into 1,4-pentadiene structures found in unsaturated fatty acids such as arachidonic NB-598 or linoleic acid [1],

• The AR signalling pathways play important roles in several p

  2025-02-26

  

  The AR signalling pathways play important roles in several physiopathological processes associated with ischaemia, inflammation, and tumourigenesis [35]. Moreover, A3AR is overexpressed in different tumour gonadotropin releasing hormone receptor and seems implicated in pro- or anti-apoptotic effect

• HT modulates cortical and hippocampal

  2025-02-26

  

  5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal butein as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 2015,

• Given these findings above we

  2025-02-26

  

  Given these findings above, we hypothesized that hypernociception produced by intra-amygdala 8-OH-DPAT is result of hyperpolarization in this area. This neuronal inhibition of the amygdaloid complex might result in an inactivation of crucial neurotransmitter systems of the descending inhibitory pain

• By performing knockdown of AXL once HER cancer

  2025-02-26

  

  By performing knockdown of AXL once HER2+ cancer Cy5 carboxylic acid (non-sulfonated) have achieved lung colonization, we demonstrated that AXL contributes to the establishment of macrometastases. While inhibition of AXL impairs the efficiency of metastasis, the later finding has major clinical imp

• Skeletal pain associated with bone fracture is another area

  2025-02-26

  

  Skeletal pain associated with bone fracture is another area of critical need for a novel pain medication. NSAIDs and opiates are the two major therapies currently used to manage bone fracture pain. However, both of these therapies lead to significant unwanted side effects. Using the osteotomy model

15845 records 3/1057 page Previous Next 12345 下5页 Last page