• We report our experience using conventional cytogenetic anal

  2020-02-21

  

  We report our experience using conventional cytogenetic analysis, FISH using EWSR1 break-apart probes, RT-PCR, and Sanger sequencing to detect characteristic translocations in a total of 32 patients with ES diagnosed at Texas Children\'s Hospital over a 5-year interval. Materials and methods R

• Therefore HNE is an attractive therapeutic target and

  2020-02-21

  

  Therefore, HNE is an attractive therapeutic target and the design of new HNE inhibitors is a demanding field that has been extensively investigated in order to provide inhibitors with new molecular architectures, including the potent oxo-β-lactam class [14]. In the present work, a coumarin-based oxo

• TKI-258 The structure of the HOIP RBR LDD module bound

  2020-02-21

  

  The structure of the HOIP RBR–LDD module bound to UbcH5~Ub reveals insights into an activated HOIP component [47]. Contacts between the E2~Ub and the non-cognate RBR module in the crystal suggest how a structure in which the active sites of the E2 and the E3 are in close proximity might look. In thi

• Another mechanism underlying on the toxicity of dopaminergic

  2020-02-21

  

  Another mechanism underlying on the toxicity of dopaminergic neurons might be related to dopamine-dependent initial oxidative stress [60]. Dopamine integrin signaling pathway mediated by monoamine oxidase (MAO) can produce hydrogen peroxide as a by-product, and excess dopamine can undergo auto-oxid

• Currently it is not known if drought induces changes

  2020-02-21

  

  Currently, it is not known if drought induces changes in the cysteine protease EW-7197 receptor of soybean nodules. The available annotation of the soybean genome, in Phytozome (www.phytozome.net) has identified 706 C1 cysteine protease sequences and 75 C13 cysteine proteases. We have previously re

• The most important cytotoxic lesion formed by the nitrogen

  2020-02-21

  

  The most important cytotoxic lesion formed by the nitrogen mustards is generally considered to be the DNA–DNA interstrand cross-link 12, 13. DNA–DNA interstrand cross-links are thought to exert their cytotoxic effects by inhibiting DNA duplex strand separation, progression of the Preladenant synthes

• In pregnancy maternal uterine spiral artery SA remodeling

  2020-02-20

  

  In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK p53 inhibitor (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in humans and

• Proof of concept studies with disulfiram

  2020-02-20

  

  Proof-of-concept studies with disulfiram suggest the potential utility of DβH inhibitors for treatment of cocaine use disorder. In a study of 74 subjects stabilized on methadone and randomized into disulfiram and placebo groups for 10weeks, disulfiram treatment reduced cocaine-positive urines, and d

• br Acknowledgements The study was supported by grant no

  2020-02-20

  

  Acknowledgements The study was supported by grant no. 501-003-11043 from the Institute of Psychiatry and Neurology in Warsaw. The authors thank Mrs. Ala Biegaj for the excellent technical assistance. Introduction In an effort to identify hIFN receptor molecules encoded by a gene(s) within hum

• NPC L NPC Niemann Pick C like like intracellular cholesterol

  2020-02-20

  

  NPC1L1 (NPC1 [Niemann-Pick C-like-1]-like intracellular cholesterol transporter) is the rate-limiting transmembrane transporter for cholesterol CHAPS from the intestinal lumen, and it mediates the absorption of both dietary and biliary cholesterol., , NPC1L1 is the target of the cholesterol-loweri

• br Conflicts of interest br Acknowledgements This work was s

  2020-02-20

  

  Conflicts of interest Acknowledgements This work was supported, in part or in whole, by the grants from the National Natural Science Foundation of China (11802056, 11772088), the China Postdoctoral Science Foundation (2018M640904), and the Fundamental Research Funds for the Central Universitie

• Multiple technologies exist for analyzing the contents

  2020-02-20

  

  Multiple technologies exist for analyzing the contents of single cells, including single-cell DNA sequencing, RNA expression analysis, and protein level and activity measurements (Hu et al., 2018; Narrandes & Xu, 2018; Ortega et al., 2017; Wang & Navin, 2015). Single-cell DNA sequencing is generally

• Films treated with Diaz ES VWFIIINle but not

  2020-02-20

  

  Films treated with Diaz-ES-VWFIIINle but not exposed to UV light supported only slight platelet deposition, suggesting that passively-bound peptides were removed under shear. However, treatment with Diaz-ES-VWFIIINle and UV restored platelet surface coverage to about 50% of the level on native colla

• CORM-3 br STAR Methods br Acknowledgments We thank the City

  2020-02-19

  

  STAR★Methods Acknowledgments We thank the City of Hope core facilities, including the Animal Model Core, Bioinformatic Core, NMR Core, Flow Cytometry Core, and Florescence Microscopy Core for excellent technical support, and NIH grants R01GM086171, R01GM102538, and R01CA212119, R01CA216987, an

• Unlike CRM exportins Cse and

  2020-02-19

  

  Unlike CRM1, exportins Cse1 and Xpot lack a C-extension and instead rely primarily on changes in HEAT-repeat conformation and direct Ran-cargo contacts to ensure low cargo-binding affinity in the cytosol and cooperative assembly of the exportin/Ran/cargo complex in the nucleus (Cook et al., 2005, Co

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