• The cysteinyl leukotrienes cysLTs LTC LTD

  2021-05-24

  

  The cysteinyl leukotrienes (cysLTs) LTC, LTD, and LTE are increased in the airways of asthmatic subjects, with the ability to induce bronchoconstriction, vascular permeability, and mucus secretion., , , , CysLTs are well established as mediators of allergic rhinitis and asthma on the basis of the ef

• Prostaglandins PGs are lipid mediators that exhibit a variet

  2021-05-24

  

  Prostaglandins (PGs) are lipid mediators that exhibit a variety of physiological properties by interacting specific G protein-coupled receptors (GPCRs) [10]. PGD2 is synthesized from PGH2 through two distinct PGD synthases; lipocalin-type PGD synthase (L-PGDS) and hematopoietic PGD synthase (H-PGDS)

• We next examined the effects of

  2021-05-24

  

  We next examined the effects of substituents around the carboxylic V5 peptide australia moiety on CRTH2 binding (Table 4). The carboxylic acid moiety shared by the representative CRTH2 antagonists and is essential for the CRTH2 activity. Germinal dimethylation of the methylene moiety next to the ca

• Crystal structures of various CRM complexes have provided in

  2021-05-24

  

  Crystal structures of various CRM1 complexes have provided insight into molecular details of the interactions between CRM1 and its interaction partners during the transport cycle. CRM1 cooperatively binds RanGTP and cargo in the nucleus (Paraskeva et al., 1999). In this ternary complex, RanGTP is lo

• The mechanism by which these HIV PIs impair skeletal muscle

  2021-05-24

  

  The mechanism by which these HIV-PIs impair skeletal muscle palmitate transport and oxidation has been partially elucidated. CD36 (also referred to as fatty DPQ translocase; FAT) is a transmembrane protein involved in the transport of long-chain fatty acids (LCFA) across cellular membranes. It has

• This work started from the

  2021-05-24

  

  This work started from the standard version of the CPA model [17] and investigated its known weaknesses: 1) not meeting the defined critical temperature, 2) missing the temperature dependence of pure component saturated liquid densities, 3) using an α function in the cubic term that can provide unr

• In the present study we

  2021-05-22

  

  In the present study we examined whether the gene for estrogen receptor alpha, Esr1, plays a role in the expression of maternal memory in female rats. The approach utilized a newly developed rat Esr1 knockout (KO) rat model (Rumi et al., 2014) to evaluate whether deletion of the Esr1 Aspartame affec

• Materials and Methods br Results br

  2021-05-22

  

  Materials and Methods Results Discussion For several decades, the diagnosis of translocation-associated childhood sarcomas with overlapping morphological characteristics has been facilitated by pathognomonic gene fusion detection through RT-PCR or FISH. However, these assays have several shor

• Herbal products may alter the metabolism of certain drugs an

  2021-05-22

  

  Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 salicin (CYP). These can bring about an alteration of the pharmacokinetics and pharmacological activi

• br Results br Discussion Previous studies have

  2021-05-22

  

  Results Discussion Previous studies have mapped ABCF1 as a risk factor gene for rheumatoid arthritis and autoimmune pancreatitis (Ota et al., 2007, Richard et al., 1998). Additionally, recent genome-wide association studies have also associated ABCF1 with the risk of gout (Dong et al., 2017) a

• Our results also showed that the highest dose of

  2021-05-22

  

  Our results also showed that the highest dose of Astressin2-B increased the rewarding effects of cocaine, since non-defeated animals treated with this dose developed CPP with a sub-threshold dose. We monitored the acute effects of 30 µg/kg of Astressin2-B and found an increase of anxiety in the open

• Rambabu et al reported A series

  2021-05-22

  

  Rambabu et al. reported A series of novel N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide derivatives synthesized from readily available 4-hydroxy coumarin to the corresponding ethyl 2-(2-oxo-2H-chromen-4-yloxy)propanoate followed by hydrolysis and further reacted with different substituted am

• For the first time we

  2021-05-21

  

  For the first time, we provide evidence for COMT Val158Met modulation of long-term fear extinction in humans, evident both in cortical (LPP) and autonomic (fear bradycardia) components of the conditioned fear response. We further found that the initial acquisition of fear is related to dispositional

• Treatment with AAV EP also improved aspects

  2021-05-21

  

  Treatment with AAV9-EP4 also improved aspects of adverse cardiac remodeling. The increased collagen deposition noted in the peri infarct and remote zone after MI was substantially attenuated by use of AAV9-EP4 and there were significant reductions in the number of macrophages and T teva 3026 infilt

• D-(-)-Salicin sale The biological actions of ET

  2021-05-21

  

  The biological actions of ET‐1 are mediated via two distinct receptor subtypes, the endothelin A and endothelin B receptors (ETA/ETB). While activation of ETA is assumed to mediate contraction of smooth muscle cells, the activity of ETB is related to transient vasodilation [22]. In human corpus cave

15942 records 639/1063 page Previous Next First page 上5页 636637638639640 下5页 Last page