• Many studies have documented that enolase acts as a

  2021-06-05

  

  Many studies have documented that enolase acts as a plasminogen-binding protein and this interaction is involved in the tissue invasion and pathogenicity of the causative agents (Almeida et al., 2004; Avilan et al., 2000; Marcilla et al., 2007; Mundodi et al., 2008; Vanegas et al., 2007). Furthermor

• br Clinical potential of ET receptor biased

  2021-06-05

  

  Clinical potential of ET receptor biased ligands Is there a clinical need for ET receptor biased ligands? Evidence is strongest from research in epithelial ovarian cancer demonstrating that ET-1 stimulated ETA-mediated β-arrestin signalling leads to activation of the oncogenic mediator NF-κB [21]

• The total reduced glutathione content was determined in

  2021-06-05

  

  The total reduced glutathione content was determined in both Edrophonium chloride to examine whether retinol was decreasing glutathione concentrations and thus decreasing the conjugation of NAPQI. Total hepatic (3.9±0.3 vs 4.9±1.0 μmol/g, retinol vs untreated, respectively) and renal (0.4±0.1 vs 0.

• As small non coding RNAs microRNAs miRNAs can control gene

  2021-06-05

  

  As small non-coding RNAs, microRNAs (miRNAs) can control gene expression at the post-transcriptional level by binding to the 3′-untranslated regions (3′-UTR) of messenger RNAs (mRNA) [15], [16]. miRNAs have been anticipated to regulate virtually all cellular mechanisms [17] and to play an important

• Nucleozin The quaternary structure of many of the family B m

  2021-06-05

  

  The quaternary structure of many of the family B members (i.e., secretin, glucagon, glucagon-like peptide and Nucleozin receptors) have been actively studied and it has been demonstrated that they can form homodimers/oligomers (Gao et al., 2009; Ng & Chow, 2015; Ng, Lee, & Chow, 2013). Harikumar, P

• DDR expression is upregulated in the glomeruli and

  2021-06-05

  

  DDR1 expression is upregulated in the glomeruli and tubules of injured kidneys [7], [8], [19]; however, what role this receptor plays in kidney resident DMH-1 is unclear. A plausible hypothesis is that DDR1 might contribute to kidney injury by directly exerting a pro-fibrotic action. In favor to th

• In vitro work by us

  2021-06-05

  

  In vitro work by us and others revealed that high affinity interaction with collagen requires dimerization and/or pre-oligomerization of DDR1 (Agarwal et al., 2007, Abdulhussein et al., 2008, Leitinger, 2003). It has also been reported that a significant percentage of the DDR1 population forms ligan

• am 580 The IL family consists of nine related

  2021-06-05

  

  The IL-10 family consists of nine related molecules: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28α, IL-28β, and IL-29 [34]. These molecules have a somewhat conserved primary structure and contain a core of hydrophobic am 580 and two pairs of disulfide bonds in the chain, giving them a similar sp

• ET expression occurs in many carcinomas including

  2021-06-04

  

  ET-1 expression occurs in many carcinomas, including those arising in the kidney [38], prostate [7], ovary [5] endometrium [39], melanocyte [40], and central nervous system [41], [42], among others [43]. The endothelin axis expression in RCC appears to be dependent upon the tumor subtype [38]. In se

• Herein we further established a dynamic DNA

  2021-06-04

  

  Herein, we further established a dynamic DNA self-assembly activated hemin-mimetic enzymes system by embedding DNA-hemin into an entropy-driven DNA-assembly for fluorescent biosensing. The entropy-driven dynamic DNA-assembly is one of the toehold-mediated isothermal strand displacement reactions, wh

• All these results indicate that

  2021-06-04

  

  All these results indicate that cleaving embryos possess a regulative mechanism, sensing the number of inner trp channel and controlling the proportion of conservative and differentiative divisions of blastomeres. The current observations agree with the results from other laboratories and our previ

• On the other hand although the

  2021-06-04

  

  On the other hand, although the cardiovascular effects of Epac have been investigated more intensely in recent years [31], there are hardly any studies that suggest or discard a participation of Epac in endothelium-dependent cAMP-induced relaxation. Only our previous results in rat FTY720 Phosphate

• br Materials and methods br Results and discussion br Conclu

  2021-06-04

  

  Materials and methods Results and discussion Conclusions Codon-optimized MGSK-Lys-C was expressed at a high level in an optimized expression system as inclusion bodies. The Lys-C activity reached its maximum with about 9340 nkat/Lculture under standard (chemical) refolding conditions. The r

• Exposure to ultraviolet radiation with sunlight is

  2021-06-04

  

  Exposure to ultraviolet radiation with sunlight is generally accepted as the major cause of basal-cell carcinoma (Gallagher et al., 1995). The risk of this disease is significantly increased by age. Skin cancers are the most common tumours of the head and neck region and their prevalence shows progr

• br Introduction br Structure of the Ku heterodimer associate

  2021-06-04

  

  Introduction Structure of the Ku heterodimer associated to DNA The atomic structure of the Ku heterodimer, alone and bound to a small DNA fragment, was recently determined (Walker et al., 2001) and has significantly improved our understanding of DNA recognition by DNA-PK holoenzyme (Fig. 3). B

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