• The pathogenesis of d penicillamine induced MG is not clear

  2025-01-24

  

  The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR LY 303511 receptor in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20%

• br AD and COX LOX pharmacology Early studies on the

  2025-01-24

  

  AD and COX/5-LOX pharmacology Early studies on the role of cyclooxygenases in AD were inspired by epidemiological data suggesting that COX inhibitors such as nonsteroidal anti-inflammatory drugs (NSAIDs) could be beneficial in AD patients (Lucca et al., 1994, McGeer et al., 1990). This line of re

• Chlorogenic acid an abundant polyphenol found in coffee and

  2025-01-23

  

  Chlorogenic Nexturastat A (7), an abundant polyphenol found in coffee and the human diet, has various biological activities including antioxidant and anticancer effects [54]. Jiang et al. reported that compound 7 had a selective cytotoxic activity on human oral tumor cells (HSG, HSC-2) as compared

• Additional support for a role of HMGN in enhancing

  2025-01-23

  

  Additional support for a role of HMGN1 in enhancing DNA repair comes from studies of transcription-coupled repair (TCR) in human cells. Lesions in the template strand of DNA induced by UV light stall the movement of RNA polymerase II (RNAPII) and interrupt transcription. Removal of these transcripti

• Finally terbinafine is generally associated with

  2025-01-23

  

  Finally, terbinafine is generally associated with a low index of toxicity and few adverse effects. In humans, only mild GI toxicity and hepatobiliary dysfunction are reported. In red-tailed hawks, oral administration of a high dose of terbinafine (120 mg/kg BW) was furthermore demonstrated to induce

• The sequential behavioral approach used in the present study

  2025-01-23

  

  The sequential behavioral approach used in the present study reinforced the involvement of the BDNF/TRKB system in the effect of losartan. In mice with dampened BDNF expression, losartan was no longer able to exert antidepressant-like effects. Similar to what was observed after losartan treatment, t

• Recent retrospective cohort studies have supported these pre

  2025-01-23

  

  Recent retrospective cohort studies have supported these preclinical findings in animals indicating the correlation of AR activation with the induction of primaquine phosphate carcinogenesis. First, men with prostate cancer who underwent androgen deprivation therapy were shown to have a significant

• In the largest postmortem study

  2025-01-23

  

  In the largest postmortem study of 3618 autopsied individuals, almost 75% of the individuals without Aβ pathology already harbored cortical NFT pathology mostly confined to the medial temporal regions (Murray et al., 2015). In Braak's study of 2366 autopsied individuals (Braak and Del Tredici, 2014)

• br Results We set out to identify in an unbiased

  2025-01-23

  

  Results We set out to identify in an unbiased manner a set of candidate “scaling factors” that might participate in transcription-dependent synaptic scaling up. The ex vivo slice and profiling studies were conducted on HsCt5 mice (described later) at postnatal day (P) 14 to P15, an age at which s

• br Guava tea leaves inhibit leukocyte type lipoxygenase acti

  2025-01-23

  

  Guava tea leaves inhibit leukocyte-type 12-lipoxygenase activity Guava tea that is extracted from guava leaves contains a number of polyphenols, and is commonly taken as a dietary supplement. The extracts show a variety of beneficial effects such as antioxidative, anti-inflammatory and antiprolif

• Glu Gln Asp and Asn the main amino acids

  2025-01-23

  

  Glu, Gln, Asp, and Asn, the main ionomycin presented in the present study, are involved in nitrogen assimilation and transport processes within the plants. Furthermore, they are used to build up reserves during periods of nitrogen availability for subsequent use in growth, defense, and reproductive

• In AD and possibly other forms of dementia it

  2025-01-23

  

  In AD, and possibly other forms of dementia, it has been suggested that tau mislocalization to dendritic spines anticipates neurodegeneration [48]. Accumulation of hyperphosphorylated tau in dendritic spies would cause a derangement of synaptic function, thereby impairing excitatory synaptic transmi

• Di ethylhexyl phthalate DEHP is one of the most widely

  2025-01-23

  

  Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used environmental chemicals in the production of polyvinyl chloride. After 2'-O-Methyl-ATP into human body, DEHP can be converted to the metabolite mono-ethylhexyl phthalate (MEHP), which has higher toxicity than DEHP and can influence r

• Derivatives of M that possess either an alkyne

  2025-01-22

  

  Derivatives of (+)-M100907 that possess either an alkyne or an azide have been synthesized. The most active enantiomer was obtained by resolution of a relatively early intermediate in the synthesis. The ability of these s1p receptor to maintain 5-HTR antagonist properties as (+)-M100907 was demonst

• The activation of the A

  2025-01-22

  

  The activation of the A2BR subtype triggers different intracellular metabolic pathways, often linked to the activation of adenylyl cyclase and increased levels of intracellular cAMP (Lynge et al., 2003, Bernareggi et al., 2015). The nAChR-channel Tenovin-1 mediated by the cAMP/PKA pathway was repor

15913 records 23/1061 page Previous Next First page 上5页 2122232425 下5页 Last page